BMI has shown an apparently positive correlation with LAD, LVEDD, LVEDS, IVST, PWT and NT-pro-BNP (rho = 0.4985, 0.3723, 0.3698, 0.3852, 0.3533 and -0.17; all p < 0.001) in spearman correlation analysis, potentially suggesting that obesity may be accompanied by cell enlargement and hypertrophy. The gene discussed is NPPB; the disease is obesity due to melanocortin 4 receptor deficiency.