We observed a clear correlation between TNF-α levels and EBV-DNA load in Malaria cases involving P. falciparum (R2 = 0.8915), but not in the P. vivax or mixed Malaria cases (R2 = 0.08050 and R2 = 0.1137, respectively) nor in the healthy controls (R2 = 0.007915). This evidence concerns the gene TNF and malaria.