Studies from sub-Sahara Africa have revealed that severe Malaria can trigger the onset of BL, which is preceded by a dysregulated immune balance and an EBV-driven oncogenic event in B-cells involving chromosomal translocation of cMYC, a key event in BL formation [8–12, 14, 21–23, 27–29]. The gene discussed is MYC; the disease is Burkitt lymphoma.