Out of the 29,017 HAE attacks of the C1‐INH‐HAE patients treated at the Center, 239 (0.8%) appeared on the lips and the tongue, 463 (1.6%) on the face, 975 (3.4%) appeared on the UAs, 987 (3.4%) appeared on the genitalia, 9288 (32%) on the gastrointestinal tract, and 17,065 (58.8%) attacks appeared in the subcutis. The gene discussed is SERPING1; the disease is hereditary angioedema.