While IPA upstream modulators analysis found the main drivers of the response for COPD were IFNγ and TGFβ1, and involvement of the oxidative stress transcriptional regulators (BCL2L1, NFE2L2/Nrf2), and extracellular matrix regulators (BMP6, ITGB6) (Figure S7B), main drivers of response for asthma were pro‐inflammatory mediators (TNF, IL‐1β, IL‐6) and the transcriptional regulators (HDAC, CAV1, MAP4k4, Wnt, and SOX2). This evidence concerns the gene IL1B and asthma.