Pathway enrichment analysis of the hits by DAVID [34] revealed statistically significant enrichment of the pathways related to DNA replication (e.g. “DNA polymerase:primase complex”, “DNA replication initiation”), “G1-S transition of mitotic cell cycle”, “PI3k-Akt signaling pathway”, “Pathways in cancer” and “Extracellular matrix organization” (Fig. 1D, Supplementary Table 2). This evidence concerns the gene AKT1 and cancer.