Is adding a dopamine reuptake inhibitor (DRI), either a monoamine oxidase type B (MAO-B) inhibitor or a catechol-O-methyltransferase (COMT) inhibitor, to levodopa therapy more effective than adding a dopamine agonist and, if a DRI is more effective, which DRI class (MAO-B or COMT) is preferable for improving patient-rated quality of life among those with motor complications of Parkinson disease (PD) that are uncontrolled by levodopa therapy? Here, MAOB is linked to Parkinson disease.