The rate of dementia onset was lower in the MAO-B group (32% [47 of 146]) compared with the COMT group (37% [54 of 145]) (RR, 0.70; 95% CI, 0.47-1.03; P = .07) (Figure 4D), as was the mortality rate for the MAO-B group (55% [80 of 146]) compared with the COMT group (63% [92 of 145]) (RR, 0.76; 95% CI, 0.56-1.03; P = .07) (Figure 4B) and the institutionalization rate for the MAO-B group (25% [37 of 146]) compared with the COMT group (31% [45 of 145]) (RR, 0.74; 95% CI, 0.48-1.15; P = .18) (Figure 4F), although none of these differences were significant. The gene discussed is COMT; the disease is dementia.