HMGCR and hyperlipidemia: 2002; Chennuru and Saleem 2013). However, PFPE could restore some parameters near to the normal range. Importantly, the PFPE sesquiterpene substance, β-caryophyllene, has been reported to effectively act as an anti-hyperlipidemia agent, same as the reference drug simvastatin, through the suppression of HMG-CoA reductase, which is the enzyme that plays a role in cholesterol synthesis (Baldissera et al. 2017).