1993). SHP2, as an intracellular response signal molecule of a variety of cytokines, growth factors and other extracellular stimuli, is widely expressed in various cells, and participates in important cellular activities, including cell proliferation, activation, migration, and differentiation (Tajan et al. 2015). Recent studies have found that SHP2 expression is increased in AML, and that the inhibition of SHP2 can improve the progression of acute leukaemia patients (Bentires-Alj et al. 2004; Richine et al. 2016). This evidence concerns the gene PTPN11 and acute myeloid leukemia.