Xu et al. transfected A549, a cell line of human lung adenocarcinoma, with PCSK9 small interfering (si)RNA and found that PCSK9 siRNA could inhibit proliferation and promote apoptosis of A549 cells by inducing endoplasmic reticulum stress and mitochondrial dysfunction.14 The gene discussed is PCSK9; the disease is lung adenocarcinoma.