The data showed upregulation of the MCAM gene in samples from cholangiocarcinoma, lymphoid neoplasm diffuse large B‐cell lymphoma, glioblastoma multiforme, head and neck squamous cell carcinoma, kidney renal clear cell carcinoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, skin cutaneous melanoma, and thymoma, compared with adjacent normal tissue samples (|log2FC|≥1, adjusted p‐value <0.05, for all tumors; Figure S1). Here, MCAM is linked to head and neck squamous cell carcinoma.