Next, we assessed the cytotoxicity of ADC aggregates in several HER2-negative cell lines—Jurkat cells (a human T lymphocyte cell line), MEG-01 s cells (a human megakaryoblastic leukemia cell line), THP-1 cells (a human acute monocytic leukemia cell line), and TMNK-1 cells (an immortalized human liver endothelial cell line)—. This evidence concerns the gene ERBB2 and adult acute megakaryoblastic leukemia.