AFP and hepatocellular carcinoma: In addition, multiROC analysis showed the survival prediction for MCM4, AFP, gender, age, stage, TNM stage, grade, and recurrence status at 1, 3, and 5 years, which could be a further proof for a better prognosis biomarker of MCM4 in HCC with high AUC at 0.69 of 1 year, 0.65 of 3 years, and 0.61 of 5 years (Figure 4(g)).