AFP and hepatocellular carcinoma: It showed the same advantage on the diagnosis of HCC than AFP (GSE19665: AUC(MCM4) = 0.8800, AUC(AFP) = 0.5100; GSE64041: AUC(MCM4) = 0.8038, AUC(AFP) = 0.6304, Figures 3(b) and 3(c)).