To obtain a standardized measure of AD neuropathology, we generated our own pathological scores based on Aβ (XAβ) and tau (Xtau) load in the frontal cortex detected using antibodies targeting Aβ40, Aβ42, and phosphorylated, mature neurofibrillary tau tangles, as outlined in Table 1. This evidence concerns the gene MAPT and Alzheimer disease.