NT-proBNP is typically influenced by age, gender, and obesity in addition to renal function [17], in our research, first, we excluded the patients with renal insufficiency, then data analysis indicated age and gender indeed had a significant difference between COPD group and AECOD-PH group, however, BMI had no significant difference (P > 0.05), it might be associated with low distribution of obesity in China. This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.