Expression of both, NRP1 and its another ligand, Sema3A, was found to be upregulated in sputum of asthmatic patients and in BAL and lung homogenates of mice with OVA-induced experimental asthma (Shim et al. 2013) suggesting NRP1 and its ligands play a pathologic role in allergic asthma (Fig. 3). This evidence concerns the gene NRP1 and allergic asthma.