LCD Type I and IC3D described variants such as Granular Corneal Dystrophy Type I (GCD1), Granular Corneal Dystrophy Type II (GCD2), a.k.a. Avellino Corneal Dystrophy, Thiel-Behnke Corneal Dystrophy (TBCD), and Reis-Bückler Corneal Dystrophy (RBCD), caused by the mutation of human transforming growth factor β-induced (TGFB-I) gene located on chromosome 5 (genetic locus 5q31). This evidence concerns the gene TGFBI and Reis-Bucklers corneal dystrophy.