AXIN1 and neoplasm: We also identified orthologs of genes that encode all major internal components of the cWnt signaling pathway [11], including disheveled, the β-catenin gene armadillo (arm), three β-catenin destruction complex genes—axin, shaggy, and Adenomatous polyposis coli tumor suppressor—and pangolin, which codes for a transcription factor that regulates the expression of targets of cWnt signaling (Table 1).