A significant increase in CXCL1 serum levels was observed in the LN group [2482.22 (1283.33–3900.12) pg/ml] and active LN group [2149.37 (1251.68–3818.64) pg/ml] compared with the non-LN group [1228.50 (400.46–1720.17) pg/ml] (p < 0.001) and inactive LN group [427.72 (186.17–2761.36) pg/ml] (p = 0.014) (Fig. 2b, c). The gene discussed is CXCL1; the disease is lobular neoplasia.