Significant increases in CXCL1 serum levels were observed in the SLE group [1492.86 (735.47–2887.34) pg/ml] compared with the OADs group [174.23 (17.07–368.40) pg/ml] (p < 0.001) and healthy controls [13.58 (8.46–37.22) pg/ml] (p < 0.001). The gene discussed is CXCL1; the disease is systemic lupus erythematosus.