Nrf2-mediated anti-inflammatory response is thought to be ROS-dependent, however a direct inhibitory effect of Nrf2 on the recruitment of RNA polymerase II, preventing the transcription of genes coding for the proinflammatory cytokines IL-1β, IL-6 [94,95,96], which is also important for the viral infections including Covid-19 [97,98]. This evidence concerns the gene NFE2L2 and viral infectious disease.