NFKB1 and colon carcinoma: In a study, it was found that the gastric cancer SGC7901, MDA-MB-231 breast cancer, and colon carcinoma (Caco 2) cell growth was inhibited by betulin as it triggered mitochondrial release of cytochrome c, mitochondrial translocation of Bak, and Bax, and down-regulation of NF-κB p50 and 65, IKKα and β, ICAM-1 and bcl-2 [56,57,58].