The accumulation of ROS can cause DNA damage, induce skin inflammatory responses, reduce antioxidant enzymes activity, influence specific survival signaling MAPK-dependent pathways, activate the AP–1 to inhibit collagen production, and increase the number of matrix metalloproteinases to decompose collagen and binding proteins in the dermis, which eventually leads to skin aging [12,14,18]. This evidence concerns the gene JUN and skin aging.