IFNG and infection: After infection, RD animals mounted a significant IFN-γ response which lasted into recovery (14 and 21 DPI), while no response was seen in HFHS animals (RD: n = 5/10, HFHS: n = 4, pre-challenge median = 629/618, 7 DPI median = 737.85/550.6, 14 DPI median = 702.3/623.55, 21 DPI median = 1042.3/609.8 pg/mL, ordinary two-way ANOVA, followed by Sidak’s multiple comparisons test, pre-challenge: p = 0.58157, 7 DPI: p = 0.0090, 14 DPI: p = 0.7373, 21 DPI p < 0.0001).