Our past studies of adenovirus infection of human corneal fibroblasts in vitro and in a mouse model of adenovirus keratitis in vivo showed early expression of CXCL8 and its murine homologue CXCL1, respectively; and CCL2, and ICAM-1, all within the first day post infection (pi) [32,75,84,109]. The gene discussed is CXCL1; the disease is infection.