FCGR2A and acute disseminated encephalomyelitis: In these cases, ADE increased the severity of diseases either by enhanced antibody-mediated virus uptake into Fc gamma receptor (FcγR)-expressing phagocytic cells, leading to increased viral infection and replication (type I ADE), or by excessive antibody Fc-mediated effector functions or immune complex formation causing enhanced inflammation and immunopathology (type II ADE) [3].