Antimalarial drugs CQ and HCQ (hydroxychloroquine) exert strong anti-SARS-CoV-2 effects in SARS-CoV-2 infected Vero E6 cells but fail to inhibit SARS-CoV-2 replication in TMPRSS2-expressing human lung cells or animal models and COVID-19 patients [37,38]. The gene discussed is TMPRSS2; the disease is COVID-19.