Based on our mathematical approach to identify relevant parameters, we selected five patient-discriminatory proteins (ADM, IL-6, MCP-3, TRAIL-R2, PD-L1) that were predictive for COVID-19 rule-in and/or hospitalization and at least for one of the following events: ICU treatment, TE, MV, and death. Here, TNFRSF10B is linked to COVID-19.