COVID-19 is scrutinized by C1q [4], likely provoked by the expression of IgG1 and IgG3 (as can be seen in anti-acetylcholine receptor antibody-mediated Myasthenia Gravis and various other complement-activating autoimmune diseases which may share common HLA haplotype mutations) to initiate the overwhelming, disproportionate, and often lethal complement-mediated immune response, which directs the MAC against the virus and injures the lungs and other end organs such as the kidney and nervous system in the process. The gene discussed is IGHG3; the disease is COVID-19.