Obesity is accompanied by chronic inflammation associated with hypoxia and adipocyte dysfunction, which resultsinappearance of pro-inflammatory cytokines such as TNF-alpha, IL-6, MCP-1, IL-1 beta and IL-17A, likely to play a role in lung injury associated with ARDS [6,7,34]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.