Regarding the anti-tumor potential of N1 cells, it has been shown that “cytotoxic neutrophils” are characterized by TNFαhigh, CCL3high, ICAM1high, and arginaselow expression [19,20] (Figure 1C) and can mediate anti-tumor functions through the production of TNF-related apoptosis-inducing ligand (TRAIL), which has been shown to induce apoptosis in Jurkat leukemic cells [21]. Here, TNFSF10 is linked to neoplasm.