CD274 and neoplasm: In a colorectal cancer murine model, generated by CT-26 cells intramuscularly injected into the flanks of BALB/c mice, neutrophils have been shown to suppress the NK cell infiltration, by downregulating CCR1 and to impair anti-tumor capabilities (Figure 2A) by cell-to-cell interactions, through the PD-L1/PD-1 axis [52] (Figure 2B).