MMP9 and neoplasm: In a transplantable tumor mouse model obtained with subcutaneous injection of melanoma and fibrosarcoma cells, Jablonska and colleagues have shown that CD11b+ neutrophils are responsible for angiogenesis stimulation since expressed high levels of genes encoding for VEGF and MMP9, together with transcription factor c-myc and STAT3, which are positive regulators of both VEGF and MMP9 [79] (Figure 3B).