TNF and Arthritis: Biological pathway analysis revealed that the upregulated DEGs were mainly enriched in influenza A, cytokine–cytokine receptor interaction, Hepatitis B and C, TNF, Toll-like receptor, and IL-17 NF-kappa B, chemokine, JAK-STAT signaling pathway, arthritis Salmonella infection, rheumatoid and tuberculosis (Figure 3D).