However, in the case of SARS-CoV-2, our results indicate that during the first hours post-infection (8 hpi to 24 hpi), rapidly available energy is consumed first for cell cycle progression (E2F1, mTOR and α-tubulin signaling) and only from around 24 hpi energy is increasingly used for virus replication (Figure 2). Here, E2F1 is linked to infection.