PTPN11 and non-small cell lung carcinoma: In another recent study, inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase (SHP)-2 within NSCLC tumours using SHP099 results in increased TIL but also increased intratumoural MDSC via increased production of CXCR2 ligands which could be prevented through the use of combined CXCR2 inhibition [195].