Later, around 2013, H10N8 and H7N9 mRNA vaccines against H10N8 influenza strain (A/Jiangxi-Donghu/346/2013) and H7N9 influenza strain (A/Anhui/1/2013) showed a robust humoral immune response in Phase 1 trials, whereby both the vaccines encoded hemagglutinin (HA) glycoprotein [143]. This evidence concerns the gene ART4 and influenza.