These GI issues were generally ascribed to the immobility associated with the progression of DMD, but since dystrophin is also expressed in neural and smooth muscle tissue of the gut [11] and because GI abnormalities have been described in mdx dystrophic mice, the most widely used animal model of DMD [12,13,14,15], a lack of dystrophin could also contribute to GI dysfunction. This evidence concerns the gene DMD and Duchenne muscular dystrophy.