These results indicate that the mechanism by which serum creatinine, but not serum CRP or albumin, is significantly associated with serum FT3/FT4 ratio, could be explained by the notion that sarcopenic HD patients exhibit lower serum FT3 by impaired local T3 generation from T4 in muscle mass resulting from lower levels of muscle mass and/or muscle activity. The gene discussed is ALB; the disease is Huntington disease.