AKT1 and erectile dysfunction: From a mechanistic point of view, the antioxidant effect of P. ginseng exerted in the corpus cavernosum of rats [34,35], associated with the restoration of Akt activity [36], and to the increased expression of eNOS and of the levels of NO and cGMP [37], have been suggested as the main contributors to the positive effects of P. ginseng in erectile dysfunction in diabetic rat models.