Comparison of our results to those of Fabian et al. [12] suggests that the magnitude of changes in weight and cancer-related biomarkers produced by LGEP, consistent with GGE, particularly changes in fasting insulin, HOMA-IR, and adiponectin, could have meaningful changes in benign breast tissue indicative of reduced postmenopausal breast cancer risk. The gene discussed is INS; the disease is breast carcinoma.