Nutrigenomics studies were performed by DNA microarray-based analyses of hippocampal samples, revealing that oral EDPC counteracted the aberrant expression of 35 genes, including Prnp, Cct4, Vegfd (Figf), Map9 (Mtap9), Pik3cg, Zfand5, Endog, and Hbq1a, which are reportedly associated with AD, CJD and/or related neurological disorders. This evidence concerns the gene PRNP and nervous system disorder.