Nutrigenomics studies were performed by DNA microarray-based analyses of hippocampal samples, revealing that oral EDPC counteracted the aberrant expression of 35 genes, including Prnp, Cct4, Vegfd (Figf), Map9 (Mtap9), Pik3cg, Zfand5, Endog, and Hbq1a, which are reportedly associated with AD, CJD and/or related neurological disorders. Here, PRNP is linked to Alzheimer disease.