The expression of other lysosomal genes was increased in CML-rich diets, such as those encoding V-ATPase, which regulate the pH of lysosomes to promote cathepsin activity, and the lysosome-associated membrane protein homolog 2 (LMP-2 or LAMP1 in mammals), which is important for the functionality of lysosomes. The gene discussed is CTSS; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.