Significantly, bromelain not only reduced the proliferation of skin cancer cells and led to their death by apoptosis but also caused a marked inhibition of cyclooxygenase-2 (COX-2) expression and inactivation of the NF-κB by blocking phosphorylation and subsequent degradation of nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor (IκBα). This evidence concerns the gene PTGS2 and skin neoplasm.