VD plays a role in insulin resistance, firstly, by stimulating the insulin receptor, and secondly, by acting on the parathyroid hormone and thus indirectly promoting dephosphorylation of the GLUT4 transporter (which diffuses circulating glucose) and by increasing the peroxisome proliferator-activated receptor delta (PPAR delta) gene, which is involved in fat cell accumulation and fatty acid oxidation [11,12,13]. This evidence concerns the gene PPARD and Insulin resistance.