Among the genes differentially regulated by ASTX in H. pylori-infected cells, insulin-like growth factor 1 receptor (IGF1R), gesolin (GSN), histone deacetylase 8 (HDAC8), signal transducer and activator of transcription 5B (STAT5B), Smad4 (SMAD4), TGF-β1 (TGFB1), Ras oncogene family (RAB 11FIP3 and RAB 40C), S-phase kinase-associated protein 2 (SKP2), polycystin2 (PKD2), Fos-like 1 (FOSL1), and c-myc (MYC) genes were notable, suggesting a possible regulatory effect of ASTX on cancer pathways. The gene discussed is SMAD4; the disease is cancer.