-Indole derivatives promote expression of anti-microbials [108]-Indoles regulate epithelial repair and differentiation [109,112]-Indoles promote IL-10 signalling to increase goblet cell differentiation and strengthen mucus barrier [113]-Indoles increase IL-10R1 expression on epithelial cells and reduces severity of DSS colitis [110]-Indoles prevent disassembly of adherens junction complexes during DSS colitis to maintain barrier integrity [114]. The gene discussed is IL10; the disease is colitis.