In the current study, using a hypercaloric diet-induced rat model, we found that long-term BJ supplementation at 25 g/day for 14 weeks afforded protective effects against prediabetes by: (i) improving glucose homeostasis and insulin sensitivity, (ii) preventing hypertriglyceridemia and liver lipid deposition, and (iii) promoting strong antioxidant effects on serum and hepatic levels. The gene discussed is INS; the disease is prediabetes syndrome.