INS and Glucose intolerance: As expected, HSuHF displayed glucose intolerance and insulin resistance as revealed by the higher glucose concentrations throughout the 2 h of GTT and ITT (Figure 1C,D, respectively) and further supported by both the significantly higher area under the curve (AUC) of GTT (p < 0.001 vs. CTRL group) (Figure 1E) and lower glucose disappearance rate (kiTT), a measure of insulin sensitivity (p < 0.01 vs. CTRL group) (Figure 1F).