It is well known that the hypoxic tumor microenvironment results in hypoxia-induced transcription factors (HIF-1α, HIF-2α)-mediated production of locally produced chemokines/cytokines [26,27,28,29,30] emanating from normal prostate epithelial cells, periprostatic adipocytes, and PCa cells. This evidence concerns the gene EPAS1 and posterior cortical atrophy.