TLR4 and posterior cortical atrophy: In ALT-100 mAb-treated mice, the levels of phosphor-NFκB in the DU145 and PC3 xenografts were markedly decreased in vivo (Figure 4E,F) confirming the involvement of the eNAMPT/TLR4/NFκB signaling pathway in these in vivo PCa xenograft tumor models.