NFE2L2 and neoplasm: Several mechanisms are involved in exerting anti-tumor action of Res, for example, inflammation suppression through NLRP3 inflammasome inhibition, cyclooxygenase (COX) curbing, nuclear factor erythroid 2-related factor 2 (Nrf2) induction, and mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) stimulation, which inhibits NF-ĸB pathway [99,106,107,108].