VEGFA and cancer: Predominantly, the anti-cancer effects of Que are linked with the modulation of PI3K/Akt/ mTOR, STAT signaling pathway, expression of heat shock protein (HSP), intracellular pH modification, regulation of apoptosis-associated proteins, and the regulation of matrix metalloproteinases (MMPs), fibronectin, and vascular endothelial growth factor (VEGF) [74,75,76].