This present study also demonstrated that APEE showed a promising protective effect against LPS-induced ALI by its anti-inflammatory, antioxidant, and anti-apoptotic effects and the underlying mechanisms for these valuable effects may be attributed to diminishing TLR-4 expression, Caspase-1/IL-1β activation, inflammatory cytokines, and restoring IL-10 and HO-1 expression levels. Here, TLR4 is linked to acute respiratory distress syndrome.