DYRK1A and cancer: Among all the synthesized compounds, compound 1g with acetylene at the 7-position of 7-deaza-4′-thioadenosine (R = acetylene) exhibited markedly potent anticancer activity in vitro against six different cancer cell lines and potent kinase inhibition of TRKA, DYRK1A/1B, and CK1δ at a concentration of 1 μM among the panel of 96 kinases.