On the other hand, SOCS1 promoter was methylated in the relapsed group of AML patients [39], and only 25% of the M5 subtype of AML patients showed a methylation status of SOCS1 promoter region with a significant variation in SOCS-1 methylation among various cytogenetic subgroups [18]. Here, SOCS1 is linked to acute myeloid leukemia.