These findings are consistent with previous studies in which SHP-1 and SOCS-3 were re-expressed in leukemia cells after 5-Azacytidine treatment [8] and support our previous findings in which TQ increased the expression of SHP-1, SOCS-1, and SOCS-3 in HL60 AML cells [32]. This evidence concerns the gene SOCS3 and acute myeloid leukemia.