In conclusion, TQ mediated anti-leukemia effects on MV4-11 AML cells by creating a balance in the expression of the epigenetic regulator genes through downregulating DNMT1, DNMT3A, and DNMT3B and upregulating TET2 and WT1, resulting in a reduction in DNA methylation levels of SHP-1 and SOCS-3 and restoration of their expression. Here, NR0B2 is linked to leukemia.