C-X-C motif chemokine receptor 4 (CXCR4), a leukocyte G-protein-coupled receptor that is involved in several inflammatory and autoimmune disorders, has also been shown to play a role in the mediation and resolution of inflammation in patients with acute myocardial infarction (MI) [94,95]. Here, CXCR4 is linked to acute myocardial infarction.