A number of studies that have been performed to screen for anti-tumour efficacy of helenalin on various adult tumour cell lines suggest that helenalin-induced cell death occurs concomitantly with mitochondrial membrane permeabilisation, ER stress accompanied by calcium discharge into cytosol, ROS generation and NF-κB deactivation [16,17,19,46]. The gene discussed is NFKB1; the disease is neoplasm.